Abstract
The synthesis of a new, potent and selective D2 dopamine receptor agonist, N-0437, of the 2-aminotetralin group is described. The results of a radioreceptor binding assay using a homogenate of porcine anterior pituitary as a tissue source for D2 dopamine receptors and3H-spiperone as radioligand demonstrate that this compound is one of the most potent compounds so far evaluated in this test system.
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Horn, A.S., Tepper, P., Van Der Weide, J. et al. Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D2 dopamine receptor agonist. Pharmaceutisch Weekblad Scientific Edition 7, 208–211 (1985). https://doi.org/10.1007/BF02307578
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DOI: https://doi.org/10.1007/BF02307578